An induction heating device using planar coil with high amplitude alternating magnetic fields for magnetic hyperthermia.

BACKGROUND Induction heating devices using the induction coil and magnetic nanoparticles (MNPs) are the way that the magnetic hyperthermia is heading. OBJECTIVE To facilitate the induction heating of in vivo magnetic nanoparticles in hyperthermia experiments on large animals. METHODS An induction heating device using a planar coil was designed with a magnetic field frequency of 328 kHz. The coil's magnetic field distribution and the device's induction heating performance on different concentrations of magnetic nanoparticles were measured. RESULTS The alternating magnetic field produced in the axis position 165 mm away from the coil center is 40 Gs in amplitude; magnetic nanoparticles with a concentration higher than 80 mg. mL-1 can be heated up rapidly. CONCLUSION Our results demonstrate that the device can be applied not only to in vitro and in small animal experiments of magnetic hyperthermia using MNPs, but also in large animal experiments.